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Overview

  • Product nameIL21 Receptor peptideSee all IL21 Receptor proteins and peptides ...

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2
  • Concentration information loading...
  • Additional notesStable for one year.
  • Sequence notesCPDLVCYTDYLQT Amino acids 20-32 of human IL-21 Receptor
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab6226 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Blocking
  • Application notesThe peptide is used for blocking the antibody activity of anti-IL-21R (cat. no ab2067). It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37°C.

    • Protein info

    • Alternative names
        CD360IL 21RIL-21 receptor
        IL-21RIL21 ReceptorIL21RIL21R_HUMANInterleukin 21 receptorInterleukin-21 receptorMGC10967NILRNovel interleukin receptor
      see all
  • FunctionThis is a receptor for interleukin-21.
  • Tissue specificitySelectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
  • Sequence similaritiesBelongs to the type I cytokine receptor family. Type 4 subfamily.
    Contains 2 fibronectin type-III domains.
  • DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Post-translational
    modifications    C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession Q9HBE5 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for IL21 Receptor peptide (ab6226)

    ab6226 has not yet been referenced specifically in any publications.

    Publishing research using ab6226 ? Please let us know so that we can cite the reference in this datasheet

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