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Products:Immunology >> Innate Immunity >> Cytokines >> Interleukins
Overview
Product name
Anti-IL31RA antibody
See all IL31RA products (2) ...
Description
Mouse monoclonal to IL31RA
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment: LPAKPENISC VYYYRKNLTC TWSPGKETSY TQYTVKRTYA FGEKHDNCTT NSSTSENRAS CSFFLPRITI PDNYTIEVEA ENGDGVIKSH MTYWRLENIA , corresponding to amino acids 21-121 of Human IL31RA
LPAKPENISC VYYYRKNLTC TWSPGKETSY TQYTVKRTYA FGEKHDNCTT NSSTSENRAS CSFFLPRITI PDNYTIEVEA ENGDGVIKSH MTYWRLENIA
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Research areas
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> STATs
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> STATs
Immunology >> Innate Immunity >> Cytokines >> Interleukins
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Western blot - IL31RA antibody (ab58119)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab58119 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity.
Tissue specificity
Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14-and CD56-positive blood cells and by macrophages (at protein level).
Sequence similarities
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 5 fibronectin type-III domains.
Post-translational
modifications
N-glycosylated.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionQ8NI17
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Class I cytokine receptor antibody
- CRL 3 antibody
- CRL antibody
see all
Database links
- Entrez Gene: 133396 Human
- Omim: 609510 Human
- SwissProt: Q8NI17 Human
- Unigene: 55378 Human
Anti-IL31RA antibody images:
Western blot - IL31RA antibody (ab58119)
Western blot against tagged recombinant protein immunogen using ab58119 IL31RA antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa
References for Anti-IL31RA antibody (ab58119)
ab58119 has not yet been referenced specifically in any publications.
Publishing research using ab58119? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"