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- Secondary antibodies
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Product name
Anti-IL6 antibody [MP5-32C11]
See all IL6 products (34) ...
Description
Rat monoclonal [MP5-32C11] to IL6
Specificity
Specifically neutralises mouse IL-6.
Tested applications
IHC-Fr, Neutralisingmore details
Cross reactivity
Reacts with
Monkey
Does not react with
Rat, Human
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
0.01M Na phosphate, 0.25M NaCl, pH7.6, 0.05% Na azide, 0.01% Thimerisol, 15mg/ml BSA
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Monoclonal
Clone number
MP5-32C11
Isotype
IgG2a
Research areas
Metabolism >> Types of disease >> Metabolic disorders
Metabolism >> Types of disease >> Cancer
Cancer >> Tumor immunology >> Cytokines >> Interleukins
Cancer >> Invasion/microenvironment >> Angiogenesis >> Angiogenic growth factors
Neuroscience >> Neurology process >> Metabolism
Immunology >> Innate Immunity >> Cytokines >> Interleukins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab7376 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr
Neutralising
Application notes
Neutralisation of mouse IL-6
This antibody is useful in immunochemical investigations of murine IL-6 in structural studies and for quantitative/qualitative immunochemical detection methods.
Target
Function
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
Involvement in disease
Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
Sequence similarities
Belongs to the IL-6 superfamily.
Post-translational
modifications
N- and O-glycosylated.
Cellular localization
Secreted.
Target information above from: UniProt accessionP05231
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Interleukin BSF 2 antibody
- B cell differentiation factor antibody
- B cell stimulatory factor 2 antibody
see all
References for Anti-IL6 antibody [MP5-32C11] (ab7376)
ab7376 has not yet been referenced specifically in any publications.
Publishing research using ab7376? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"