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Overview

  • Product nameIL6 protein (His tag)See all IL6 proteins and peptides ...
  • Protein descriptionRecombinant fusion protein, corresponding to amino acids 29-211 of Human mature IL6 with an N terminal hexahistidine tag, (184 amino acids).
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab53327 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        Interleukin BSF 2B cell differentiation factorB cell stimulatory factor 2
        B-cell stimulatory factor 2BSF 2BSF-2BSF2CDFCTL differentiation factorCytotoxic T cell differentiation factorHepatocyte stimulating factorHGFHPGFHSFHybridoma growth factorHybridoma growth factor Interferon beta-2Hybridoma plasmacytoma growth factorIFN-beta-2IFNB2IL 6IL-6IL6IL6 proteinIL6_HUMANInterferon beta 2Interferon beta-2Interleukin 6Interleukin 6 (interferon beta 2)Interleukin-6Interleukin6
      see all
  • FunctionCytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
  • Involvement in diseaseGenetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
    Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
  • Sequence similaritiesBelongs to the IL-6 superfamily.
  • Post-translational
    modifications    N- and O-glycosylated.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P05231 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    IL6 protein (His tag) images

    • SDS-PAGE - IL6 protein (His tag) (ab53327)
      SDS-PAGE - IL6 protein (His tag) (ab53327)

    References for IL6 protein (His tag) (ab53327)

    ab53327 has not yet been referenced specifically in any publications.

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