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Overview

  • Product nameAnti-IL6R antibody
  • Description
    Rabbit polyclonal to IL6R
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A 16 amino acid peptide from near the intermediate residues of Human IL6R protein (NM_000565.2)

  • Positive controlJurkat cell lysate, 803 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab85105 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/200 - 1/500. Detects a band of approximately 60 kDa (predicted molecular weight: 52 kDa).

Target

  • RelevanceIL6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
  • Cellular localizationIsoform 1: Cell membrane; basolateral cell membrane; single-pass type I membrane protein. Isoform 2: Secreted protein
  • Database links
    • Alternative names
        CD126 antibodyCD126 antigen antibodygp80 antibody
        IL 6R alpha antibodyIL-6R-1 antibodyIL-6R-alpha antibodyIL6R1 antibodyIL6RA antibodyIL6Ralpha antibodyInterleukin 6 receptor antibodyMGC104991 antibodyOTTHUMP00000034320 antibody
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    Anti-IL6R antibody images

    References for Anti-IL6R antibody (ab85105)

    ab85105 has not yet been referenced specifically in any publications.

    Publishing research using ab85105 ? Please let us know so that we can cite the reference in this datasheet

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    Has this antibody been tested in any other lysates besides the Jurkat and 803 cell lines shown on the datasheet?

    Thank you for your call yesterday and for your patience while I have been in touch with the lab regarding ab85105.



    The antibody has also been tested with fetal liver lysate, which was also positive with the antibody. At this time we d...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"