Anti-IL8 antibody [MM0219-7F11] (ab89336)

Overview

• Product nameAnti-IL8 antibody [MM0219-7F11]See all IL8 primary antibodies ...
• Description
  Mouse monoclonal [MM0219-7F11] to IL8
• Tested applicationsWB, IHC-Fr, Neutralising, Flow Cyt more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant full length protein: GAVLPRSAK ELRCQCIKTY SKPFHPKFI K ELRVIESG PH CANTEII VKL SDGREL CLDP KENWV QRVVE KFLK RAENS , corresponding to amino acids 22-98 of Human IL8

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Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: PBS
• Concentration information loading...
• PurityProtein G purified
• Purification notesThe IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution.
• Clonality Monoclonal
• Clone numberMM0219-7F11
• IsotypeIgG1
• Research Areas
  • Cancer
  • Invasion/microenvironment
  • Angiogenesis
  • Angiogenic growth factors

  • Cardiovascular
  • Angiogenesis
  • Cytokines
  • Interleukin

  • Immunology
  • Innate Immunity
  • Cytokines
  • Interleukins

Applications

Target

• FunctionIL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
• Sequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family.
• Post-translational
  modificationsSeveral N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.
• Cellular localizationSecreted.

Target information above from: UniProt accession P10145 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 3576 Human
  • Omim: 146930 Human
  • SwissProt: P10145 Human
  • Unigene: 624 Human

• Alternative names
  (Ala-IL-8)77 antibody(Ser-IL-8)72 antibodyBbeta thromboglobulin like protein antibody

  C-X-C motif chemokine 8 antibodyCXCL8 antibodyEmoctakin antibodyGCP-1 antibodyGCP/IL-8 protein I antibodyGCP/IL-8 protein II antibodyGCP/IL-8 protein III antibodyGCP/IL-8 protein IV antibodyGCP/IL-8 protein V antibodyGCP/IL-8 protein VI antibodyGCP1 antibodyGranulocyte chemotactic protein 1 antibodyIL-8 antibodyIL-8(1-77) antibodyIL-8(9-77) antibodyIL8 antibodyIL8/NAP1 form I antibodyIL8/NAP1 form II antibodyIL8/NAP1 form III antibodyIL8/NAP1 form IV antibodyIL8/NAP1 form V antibodyIL8/NAP1 form VI antibodyIL8_HUMAN antibodyInteleukin 8 antibodyLECT antibodyLUCT antibodyLymphocyte-derived neutrophil-activating factor antibodyLYNAP antibodyMDNCF antibodyMDNCF-b antibodyMDNCF-c antibodyMONAP antibodyMonocyte-derived neutrophil chemotactic factor antibodyMonocyte-derived neutrophil-activating peptide antibodyNAF antibodyNAP-1 antibodyNAP1 antibodyNeutrophil activating peptide 1 antibodyNeutrophil activating protein 1 antibodyNeutrophil-activating factor antibodyNeutrophil-activating protein 1 antibodyProtein 3 10C antibodyProtein 3-10C antibodySCYB8 antibodySmall inducible cytokine subfamily B member 8 antibodyT cell chemotactic factor antibodyT-cell chemotactic factor antibodyTSG1 antibody

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Anti-IL8 antibody [MM0219-7F11] images

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  Immunohistochemistry (Frozen sections) - Anti-IL8 antibody [MM0219-7F11] (ab89336)Image from Negi S et al., PLoS One. 2012;7(1):e30415. Epub 2012 Jan 27. Fig 4.; doi:10.1371/journal.pone.0030415; January 27, 2012, PLoS ONE 7(1): e30415.
  Immunofluorescence analysis of Human pancreas (left panels), freshly isolated d0-islets (centre panels) and cultured d3-islets (right panels). IL8 was stained using ab89336 at 1/50 dilution.