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Overview

  • Product nameIL8 proteinSee all IL8 proteins and peptides ...
  • Protein descriptionRecombinant full length Pig IL8 produced in yeast; amino acids 26-103, 78 amino acids, Predicted MWt 9.1kDa (UniProt P26894).
  • Expression hostYeast

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesPurified by Ion-exchange chromatography
  • FormLyophilised:Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
  • Storage instructionsStore at -20°C. Stable for 12 months at -20°C
  • Storage bufferPreservative: None
    Constituents: 10% Trehalose, 1X PBS
  • Concentration information loading...
  • Additional notesReconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
  • Sequence notesARVSAELRCQ CINTHSTPFH PKFIKELRVI ESGPHCENSE IIVKLVNGKE VCLDPKEKWV QKVVQIFLKR TEKQQQQQ
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab90394 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        (Ala-IL-8)77(Ser-IL-8)72Bbeta thromboglobulin like protein
        C-X-C motif chemokine 8CXCL8EmoctakinGCP-1GCP/IL-8 protein IGCP/IL-8 protein IIGCP/IL-8 protein IIIGCP/IL-8 protein IVGCP/IL-8 protein VGCP/IL-8 protein VIGCP1Granulocyte chemotactic protein 1IL-8IL-8(1-77)IL-8(9-77)IL8IL8/NAP1 form IIL8/NAP1 form IIIL8/NAP1 form IIIIL8/NAP1 form IVIL8/NAP1 form VIL8/NAP1 form VIIL8_HUMANInteleukin 8LECTLUCTLymphocyte-derived neutrophil-activating factorLYNAPMDNCFMDNCF-bMDNCF-cMONAPMonocyte-derived neutrophil chemotactic factorMonocyte-derived neutrophil-activating peptideNAFNAP-1NAP1Neutrophil activating peptide 1Neutrophil activating protein 1Neutrophil-activating factorNeutrophil-activating protein 1Protein 3 10CProtein 3-10CSCYB8Small inducible cytokine subfamily B member 8T cell chemotactic factorT-cell chemotactic factorTSG1
      see all
  • FunctionIL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
  • Sequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family.
  • Post-translational
    modifications    Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P10145 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for IL8 protein (ab90394)

    ab90394 has not yet been referenced specifically in any publications.

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