Anti-IRAK2 antibody (ab6158)

Product name

Anti-IRAK2 antibody
See all IRAK2 products (8) ...

Description

Rabbit polyclonal to IRAK2

Specificity

Anti-IRAK2 has no crossresponse to IRAK.

Tested applications

ICC/IF, WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Positive control

K562whole cell lysate

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS with 0.02% sodium azide

Concentration

Concentration information loading...

Purity

IgG fraction

Purification notes

Purified IgG prepared by ion exchange chromatography.

Primary antibody notes

Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFa, and bacteria product LPS. NF-kB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kB activity. The long-sought IkB kinase (IKK),which phosphorylates IkB, and mediates IkB degradation and NF-kB activation, was recently identified by several laboratories (1-5). IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKa and IKKb). IKKa and IKKb interact with each other and both are essential for NF-kB activation. IKKb phosphorylates both IkB-a and IkB-b. IKKb is expressed in a variety of human tissues.

Clonality

Polyclonal

Isotype

IgG

Research areas

Immunology >> Innate Immunity >> TLR Signaling
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Immunology >> Innate Immunity >> Cytokines >> Interleukins