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- Secondary antibodies
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Product name
Anti-IRAKM antibody
See all IRAKM products (10) ...
Description
Rabbit polyclonal to IRAKM
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Human
Immunogen
A KLH conjugated synthetic peptide selected from aa 60~77 of human IRAKM (N Terminal).
Positive control
HL-60 cell lysate
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Purification notes
This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Immunology >> Innate Immunity >> Cytokines >> Interleukins
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Western blot - IRAKM antibody (ab37809)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab37809 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/100 - 1/500. Detects a band of approximately 68 kDa (predicted molecular weight: 68 kDa).
ELISA
ELISA: 1/1000.ELISA: 1/1000.
Target
Function
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Tissue specificity
Expressed predominantly in peripheral blood lymphocytes.
Involvement in disease
Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Contains 1 death domain.
Contains 1 protein kinase domain.
Target information above from: UniProt accessionQ9Y616
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- IL 1 receptor associated kinase M antibody
- IL-1 receptor-associated kinase M antibody
- Interleukin 1 Receptor Associated Kinase 3 antibody
see all
Database links
- Entrez Gene: 11213 Human
- Omim: 604459 Human
- SwissProt: Q9Y616 Human
- Unigene: 369265 Human
Anti-IRAKM antibody images:
Western blot - IRAKM antibody (ab37809)
Anti-IRAKM antibody (ab37809) at 1/100 dilution + HL-60 cell lysate
Predicted band size : 68 kDa
Observed band size : 68 kDa
Additional bands at : 37 kDa. We are unsure as to the identity of these extra bands.
Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
References for Anti-IRAKM antibody (ab37809)
ab37809 has not yet been referenced specifically in any publications.
Publishing research using ab37809? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"