Anti-ITIH2/SHAP antibody (ab118257)
Key features and details
- Rabbit polyclonal to ITIH2/SHAP
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ITIH2/SHAP antibody
See all ITIH2/SHAP primary antibodies -
Description
Rabbit polyclonal to ITIH2/SHAP -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant fragment corresponding to Human ITIH2/SHAP aa 124-321.
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Positive control
- WB: Fetal brain lysate IHC-P: Fetal brain tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab118257 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa).
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IHC-P |
1/100 - 1/500.
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Notes |
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WB
1/500 - 1/1000. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa). |
IHC-P
1/100 - 1/500. |
Target
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Function
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. -
Tissue specificity
Plasma. -
Sequence similarities
Belongs to the ITIH family.
Contains 1 VIT domain.
Contains 1 VWFA domain. -
Post-translational
modificationsHeavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
Phosphorylation sites are present in the extracelllular medium. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 3698 Human
- Entrez Gene: 16425 Mouse
- Omim: 146640 Human
- SwissProt: P19823 Human
- SwissProt: Q61703 Mouse
- Unigene: 75285 Human
- Unigene: 182043 Mouse
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Alternative names
- AI747202 antibody
- H2P antibody
- IGHEP2 antibody
see all
Images
Protocols
Datasheets and documents
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Datasheet download
References (3)
ab118257 has been referenced in 3 publications.
- Heindel DW et al. Glycomic Analysis Reveals a Conserved Response to Bacterial Sepsis Induced by Different Bacterial Pathogens. ACS Infect Dis 8:1075-1085 (2022). PubMed: 35486714
- Martin J et al. Tumor Necrosis Factor-stimulated Gene 6 (TSG-6)-mediated Interactions with the Inter-a-inhibitor Heavy Chain 5 Facilitate Tumor Growth Factor ß1 (TGFß1)-dependent Fibroblast to Myofibroblast Differentiation. J Biol Chem 291:13789-801 (2016). PubMed: 27143355
- He H et al. Immobilized heavy chain-hyaluronic acid polarizes lipopolysaccharide-activated macrophages toward M2 phenotype. J Biol Chem 288:25792-803 (2013). WB ; Human . PubMed: 23878196