Overview

  • Product name
    ITSA-1
  • Description
    Cell-permeable HDAC activator. Selective Trichostatin A suppressor.
  • Biological description
    Cell-permeable HDAC activator. Selective Trichostatin A (ab120850) suppressor. Counteracts Trichostatin A-induced cell cycle arrest. Inhibits Trichostatin A-induced tubulin acetylation. Shows no effect on the activity of other HDAC inhibitors.
  • Purity
    > 98%

Properties

  • Chemical name
    Benzotriazol-1-yl-(2,4-dichlorophenyl)methanone
  • Molecular weight
    292.12
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C13H7Cl2N3O
  • CAS Number
    200626-61-5
  • PubChem identifier
    771910
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Koeller KM  et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. Chem Biol 10:397-410 (2003). Read more (PubMed: 12770822) »
  • Haggarty SJ  et al. Small molecule modulation of the human chromatid decatenation checkpoint. Chem Biol 10:1267-79 (2003). Read more (PubMed: 14700634) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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