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Overview

  • Product nameIba1 protein (His tag)See all Iba1 proteins and peptides ...
  • Protein descriptionRecombinant full length Human Iba1 (amino acids 2-147) with N terminal His tag; 155aa, 17.7kDa.
  • Uniprot accessionP55008
  • Molecular weight17.700kDa inclusive of tags
  • Protein length146 amino acids
  • Expression hostE. coli

    • Properties

  • Purity> 90 % by SDS-PAGE
  • FormLyophilised:Add 0.2 ml of deionized water and let the lyophilized pellet dissolve completely. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles.
    Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized protein remains stable for 24 months when stored at -20°C.
  • Storage instructionsShipped at 4°C. Store at -20ºC.
  • Storage bufferpH: 7.50
    Constituents: 0.32% Tris, 0.29% Sodium chloride
  • Concentration information loading...
  • Sequence notesMKHHHHHHASQTRDLQGGKAF­GLLKAQQEERLDE­INKQ FLDDPKYSSDED­LPSKLEGFKEKYMEF­DLNGNGDIDIM SLKRMLEK­LGVPKTHLELKKLI­GEVSSGSGETFSYP­D FLRMMLGKRSAIL­KMILMYEEKAREKEK­PTGPPAKKAI SELP
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab117478 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent dilution.
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
  • Application notesThis peptide can be used with studies using ab5076,ab48004,ab107159,ab153696 and ab166989.

    • Protein info

    • Alternative names
        AIF 1AIF-1Aif1
        AIF1 proteinAIF1_HUMANAllograft inflammatory factor 1Allograft inflammatory factor 1 splice variant Gallograft inflammatory factor-1 splice variant Hara-1balloon angioplasty responsive transcriptionBART 1G1G1 putative splice variant of allograft inflamatory factor 1IBA 1IBA1interferon gamma responsive transcriptinterferon responsive transcript factor 1Ionized calcium binding adapter molecule 1ionized calcium-binding adapter moleculeIonized calcium-binding adapter molecule 1IRT 1IRT1Microglia response factorMRF1Protein g1
      see all
  • FunctionActin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
  • Tissue specificityDetected in T-lymphocytes and peripheral blood mononuclear cells.
  • Sequence similaritiesContains 2 EF-hand domains.
  • Post-translational
    modifications    Phosphorylated on serine residues.
  • Cellular localizationCytoplasm > cytoskeleton. Cell projection > ruffle membrane. Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

    • Target information above from: UniProt accession P55008 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for Iba1 protein (His tag) (ab117478)

    ab117478 has not yet been referenced specifically in any publications.

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