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Product Name
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Importin 13 peptide (951-963)
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Product type
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Proteins and Peptides
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Peptide
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Synthetic peptide: CRGLHGTDYTADY, corresponding to C terminal amino acids 951-963 of Human Importin 13. This peptide was used as an immunogen for ab21693 - Importin 13 antibody.
BLAST 'CRGLHGTDYTADY' with  or 
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Research areas
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Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Nuclear Pore Complex
Signal Transduction >> Metabolism >> Plasma Membrane >> Channels
Signal Transduction >> Protein Trafficking >> Nuclear Import / Export
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Relevance
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Importin 13 functions in nuclear protein import as a nuclear transport receptor. It serves as a receptor for nuclear localization signals (NLS) in cargo substrates. Importin 13 is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin, and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Importin 13 also mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. It also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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