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Importin 13 peptide (951-963) (ab45564)

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Overview

Product name

Importin 13 peptide (951-963)

Protein description

Synthetic peptide: CRGLHGTDYTADY, corresponding to C terminal amino acids 951-963 of Human Importin 13. This peptide was used as an immunogen for ab21693 - Importin 13 antibody.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Concentration

Concentration information loading...

Sequence

CRGLHGTDYT ADY

Research areas

Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Nuclear Pore Complex
Signal Transduction >> Metabolism >> Plasma Membrane >> Channels
Signal Transduction >> Protein Trafficking >> Nuclear Import / Export

Protein info

Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.

Tissue specificity

Expressed in fetal brain, heart, intestine and kidney.

Sequence similarities

Belongs to the importin beta family.
Contains 14 HEAT repeats.
Contains 1 importin N-terminal domain.

Cellular localization

Cytoplasm. Nucleus.

Target information above from: UniProt accessionO94829 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

References for Importin 13 peptide (951-963) (ab45564)

ab45564 has not yet been referenced specifically in any publications.

Publishing research using ab45564? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"