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Products:Microbiology >> Organism >> Virus >> RNA Virus >> single stranded RNA negative strand virus >> Influenza
Overview
Product name
Anti-Influenza A Virus M1 antibody (HRP)
See all Influenza A Virus M1 products (4) ...
Description
Goat polyclonal to Influenza A Virus M1 (HRP)
Conjugation
HRP
Conjugation notes
Ab21008 is covalently coupled to a highly purified preparation of horseradish peroxidase (RZ>3). Care is taken to ensure adequate conjugation while preserving maximum enzyme activity. Free enzyme is removed.
Specificity
Ab21008 recognizes the matrix protein (M) for any strain of Influenza A. Conservation of the matrix protein sequence between hemagluttinin/Neuraminidase typed strains. Does not react with HEp-2 cells by indirect immunofluorescence.
Tested applications
ELISA, IF, WBmore details
Cross reactivity
Does not react with Influenza B, Adenovirus, Respiratory syncytial virus and Parainfluenza viruses (1-3). Not yet tested in other species.
Immunogen
Influenza A-Phillipines (H3N2).
General notes
Use of sodium azide as a preservative will substantially inhibit the enzyme activity of horseradish peroxidase.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.002% Thimerosal (merthiolate)
Constituents: PBS, 10mg/ml BSA
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Microbiology >> Organism >> Virus >> RNA Virus >> single stranded RNA negative strand virus >> Influenza
Applications
Show applications key
Our Abpromise guarantee covers the use of ab21008 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
IF
WB
Application notes
ELISA: Use at an assay dependent dilution.
IF: Use at an assay dependent dilution.
WB: Use at a concentration of 1 µg/ml (PMID 19234203).
Is unsuitable for IHC.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
Influenza virus type A matrix protein, also known as M1, is composed of a 252 amino acid sequence and is type-specific in influenza viruses. It is located inside the viral lipid envelope and plays a key role in virus assembly and replication. M1 can be isolated from particles by removing the envelope with detergents and reducing the pH to 4.0. Influenza viruses are a common and widely spread infectious agent. Like many other viruses, influenza virus are constantly undergoing mutations and thereby avoiding the immune system. The Influenza A Virus M proteins form a continuous shell on the inner side of the lipid bilayer, maintaining the structural integrity of the virus particle through hydrophobic interactions.
Cellular localization
Cytoplasmic
Alternative names
- FLUAVAHHH9N2s7gp2 antibody
- FLUAVs7gp1 antibody
- M1 antibody
see all
References for Anti-Influenza A Virus M1 antibody (HRP) (ab21008)
This product has been referenced in:
- Poon LLet al. Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in mice. J Immunol 182:3063-71 (2009). WB.Read more (PubMed: 19234203) »
See 1 publication for this product
Publishing research using ab21008? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"