Anti-Insulin antibody [INSC7C9] (ab20371)
- Product nameAnti-Insulin antibody [INSC7C9]See all Insulin primary antibodies ...
- DescriptionMouse monoclonal [INSC7C9] to Insulin
- SpecificityReacts with C-terminal pentapeptide of insulin beta chain.
- Tested applicationsELISA more details
- Species reactivityReacts with: Cow, Human, Pig
Purified human insulin, C-terminal.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferPreservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4
- Concentration information loading...
- PurityProtein A purified
- Clonality Monoclonal
- Clone numberINSC7C9
- Light chain typekappa
Our Abpromise guarantee covers the use of ab20371 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionInsulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
- Involvement in diseaseDefects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730].
Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
- Sequence similaritiesBelongs to the insulin family.
- Cellular localizationSecreted.
- IDDM2 antibodyILPR antibodyINS antibody
- INS_HUMAN antibodyInsulin A chain antibodyInsulin B chain antibodyInsulin precursor antibodyIRDN antibodyMODY10 antibodyProinsulin antibodyProinsulin precursor antibody
References for Anti-Insulin antibody [INSC7C9] (ab20371)
ab20371 has not yet been referenced specifically in any publications.