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Overview

  • Product nameAnti-Insulin antibody [INSC7C9]See all Insulin primary antibodies ...
  • Description
    Mouse monoclonal [INSC7C9] to Insulin
  • SpecificityReacts with C-terminal pentapeptide of insulin beta chain.
  • Tested applicationsELISA more details
  • Species reactivity
    Reacts with: Cow, Human, Pig
  • Immunogen

    Purified human insulin, C-terminal.

Properties

Applications

Our Abpromise guarantee covers the use of ab20371 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA
  • Application notesELISA: Use at an assay dependent dilution. Can be used for the detection of insulin in two-site enzyme immunoassay.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionInsulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    • Involvement in diseaseDefects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730].
      Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
      Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
      Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    • Sequence similaritiesBelongs to the insulin family.
    • Cellular localizationSecreted.

      • Target information above from: UniProt accession P01308 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      see all
    • Alternative names
        IDDM2 antibodyILPR antibodyINS antibody
        INS_HUMAN antibodyInsulin A chain antibodyInsulin B chain antibodyInsulin precursor antibodyIRDN antibodyMODY10 antibodyProinsulin antibodyProinsulin precursor antibody
      see all

    References for Anti-Insulin antibody [INSC7C9] (ab20371)

    ab20371 has not yet been referenced specifically in any publications.

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