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Anti-Integrin alpha 3+beta 1 antibody [P1B5] (ab24696)

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Overview

Product name

Anti-Integrin alpha 3+beta 1 antibody [P1B5]

Description

Mouse monoclonal [P1B5] to Integrin alpha 3+beta 1

Specificity

This antibody recognises the alpha 3 subunit

Tested applications

IP, IF, IHC-Fr, Flow Cytmore details

Cross reactivity

Reacts with

Human

Immunogen

Human HT1080 cells.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Ascites

Concentration

Concentration information loading...

Purity

Ascites

Clonality

Monoclonal

Clone number

P1B5

Isotype

IgG1

Research areas

Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Integrins >> Beta
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Integrins >> Alpha

Applications

Show applications key

Our Abpromise guarantee covers the use of ab24696 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

Integrin alpha V/beta 3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha IIB/beta 3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha IIB/beta 3 and alpha V/beta 3 recognise the sequence R G D in a wide array of ligands. Integrin alpha IIB/beta 3 recognises the sequence H H L G G G A K Q A G D V in fibrinogen gamma chain. Following activation integrin alpha IIB/beta 3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.

Cellular localization

Type I membrane protein

Alternative names

  • alpha 3 subunit of VLA 3 receptor antibody
  • CD49C antibody
  • fibronectin receptor antibody
  • Fibronectin receptor beta subunit antibody
  • Galactoprotein B3 antibody
  • GAPB3 antibody
  • Integrin VLA 4 beta subunit antibody
  • VL3A antibody
  • VLA 3 alpha chain antibody
  • VLA3a antibody
see all

Database links

References for Anti-Integrin alpha 3+beta 1 antibody [P1B5] (ab24696)

This product has been referenced in:

  • Xie Pet al. Role of Extracellular Matrix Renal Tubulo-interstitial Nephritis Antigen (TINag) in Cell Survival Utilizing Integrin {alpha}v{beta}3/Focal Adhesion Kinase (FAK)/Phosphatidylinositol 3-Kinase (PI3K)/Protein Kinase B-Serine/Threonine Kinase (AKT) Signaling Pathway. J Biol Chem 286:34131-46 (2011). WB; Human.Read more (PubMed: 21795690) »
  • Araki Eet al. Clustering of syndecan-4 and integrin beta1 by laminin alpha 3 chain-derived peptide promotes keratinocyte migration. Mol Biol Cell 20:3012-24 (2009). Inhibition Assay; Human.Read more (PubMed: 19403697) »

See all 4 publications for this product

Publishing research using ab24696? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"