Integrin alpha 4 antibody [PS/2] (Biotin) (ab24944)

Product Name 

Integrin alpha 4 antibody [PS/2] (Biotin)

Product type 

Primary antibodies

Description 

Rat monoclonal [PS/2] to Integrin alpha 4 (Biotin)

Immunogen 

The details of the immunogen for this antibody are not available.

Reacts with 
(species key)

Hu, Ms

Specificity 

ab24944 recognises Integrin alpha 4.

Tested applications 
(see key)

Flow Cyt, FuncS, IP, Inhib

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
Flow Cyt: Use 2µl for 10⁶ cells.
FuncS (studies of cell-cell interaction and tumor cell metastasis and adhesion;
Retardation of myelopoiesis in Dexter-type cultures). Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
Inhib (Inhibition of lymphopoiesis in Whitlock-Witte long-term bone marrow cultures): Use at an assay dependent dilution.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Type I membrane protein

Research areas 

Stem Cells >> Neural Stem Cells >> Surface Molecules
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Integrins >> Alpha
Immunology >> Cell Type Markers >> CD >> Non-lineage

Relevance 

Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery.

Database links 

Raised in 

Rat

Clonality 

Monoclonal

Clone number 

PS/2

Isotype 

IgG2b

Light chain type 

kappa

Purity 

IgG fraction

Storage buffer 

Preservative: 0.1% Sodium Azide
Constituents: PBS

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Conjugation 

Biotin

Concentration 

0.500 mg/ml

Storage instructions 

Store at +4°C in the dark.

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