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Product Name
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Integrin alpha 5 antibody [5H10-27] (Phycoerythrin)
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See all Integrin alpha 5 antibodies (18)...
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Product type
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Primary antibodies
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Description
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Rat monoclonal [5H10-27] to Integrin alpha 5 (Phycoerythrin)
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Immunogen
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Tissue / cell preparation: C57BL/6 x A/J F1 mouse mast cell line MC/9
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Reacts with
(species key)
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Ms
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Specificity
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ab25461 recognises CD49e, the alpha 5 subunit of the integrin alpha 5 beta 1 fibronectin receptor.
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Tested applications
(see key)
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BL, CellAct, Flow Cyt, ICC/IF, IHC-Fr
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Abreviews
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Application notes
(see key)
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Recommended dilutions
BL: Use at an assay dependent dilution.
Note: ab25461 can be used for in vitro blocking of adhesion.
Cellular activation: Use at an assay dependent dilution.
Note: ab25461 can be used for T cell co-stimulation
Flow Cyt: Use 0.3µg for 106 cells.
ICC/IF: 1/150.
IHC-Fr: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Type I membrane protein.
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Research areas
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Stem Cells >> Endothelial Progenitors >> Endothelial Markers
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Mast Cell Lineage
Signal Transduction >> Adapters >> Transmembrane
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Integrins >> Alpha
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Relevance
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Integrin alpha 5 belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell surface mediated signalling.
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Integrin alpha 5 antibody [5H10-27] (Phycoerythrin) (ab25461) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rat
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Clonality
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Monoclonal
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Clone number
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5H10-27
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Isotype
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IgG2a
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Light chain type
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kappa
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Purity
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IgG fraction
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Storage buffer
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Preservative: 0.09% Sodium Azide
Constituents: 16% Sucrose, PBS; Stabilizing agent Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Conjugation
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Phycoerythrin
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Concentration
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0.100 mg/ml
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Storage instructions
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Store at +4°C in the dark. Do not freeze.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Integrin alpha 5 antibody [5H10-27] (Phycoerythrin) is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Integrin alpha 5
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