![Western blot - Integrin alpha E antibody [EPR4166] (ab108503) image](#Integrin-alpha-E-Primary-antibodies-ab108503-1.jpg)
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Product name
Anti-Integrin alpha E antibody [EPR4166]
See all Integrin alpha E products (15) ...
Description
Rabbit monoclonal [EPR4166] to Integrin alpha E
Tested applications
Cross reactivity
Reacts with
Human
Does not react with
Mouse, Rat
Immunogen
A synthetic peptide corresponding to the extracellular domain and light chain region of Human Integrin alpha E.
Positive control
HuT-78, Jurkat, 431, HeLa and K562 cell lysates.
General notes
Produced under U.S. Patent No. 5,675,063.
Properties
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Storage buffer
PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purity
Tissue culture supernatant
Clonality
Monoclonal
Clone number
EPR4166
Isotype
IgG1
Research areas
Immunology >> Adaptive Immunity >> Regulatory T Cells
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> T Lymphocytic Lineage
Immunology >> Cell Type Markers >> CD >> Adhesion
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Integrins >> Alpha
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Western blot - Integrin alpha E antibody [EPR4166] (ab108503)
![Western blot - Integrin alpha E antibody [EPR4166] (ab108503) image](/ps/datasheet/images/108/ab108503/Integrin-alpha-E-Primary-antibodies-ab108503-1.jpg)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab108503 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000 - 1/10000. Detects a band of approximately 150 kDa (predicted molecular weight: 130 kDa).
Application notes
Is unsuitable for ,Flow Cyt,ICC,IHC-P or IP.
Target
Function
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
Tissue specificity
Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.
Sequence similarities
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.
Domain
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Cellular localization
Membrane.
Target information above from: UniProt accessionP38570
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- A530055J10 antibody
- alpha-E1 antibody
- alpha-M290 antibody
see all
Database links
- Entrez Gene: 3682 Human
- Omim: 604682 Human
- SwissProt: P38570 Human
- Unigene: 513867 Human
Anti-Integrin alpha E antibody [EPR4166] images:
Western blot - Integrin alpha E antibody [EPR4166] (ab108503)
All lanes : Anti-Integrin alpha E antibody [EPR4166] (ab108503) at 1/1000 dilution
Lane 1 : HuT-78 cell lysate
Lane 2 : Jurkat cell lysate
Lane 3 : A431 cell lysate
Lane 4 : HeLa cell lysate
Lane 5 : K562 cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size : 130 kDa
Observed band size : 150 kDa (why is the actual band size different from the predicted?)
References for Anti-Integrin alpha E antibody [EPR4166] (ab108503)
ab108503 has not yet been referenced specifically in any publications.
Publishing research using ab108503? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"