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Anti-Integrin beta 1 antibody [P4G11] (ab78502)

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1 question for ab78502

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Question 1

Wednesday 16-May-2012

Customer kindly called to inquire whether our Intergin beta 1 antibodies were conformationally specific, e.g recognized only the active or inactive forms.

ANSWER:

 

Thank you for contacting Abcam. I have a response from the lab regarding conformational specificity of our Integrin beta 1 products.

ab30394 Anti-Integrin beta 1 antibody [12G10]is conformation-specific, and it recognizes the subset of beta1 integrins with high affinity for ligand (i.e. activated). In fact, it is the best antibody for this purpose because it binds close to the ligand-binding site, and the expression of its epitope is exquisitely regulated by divalent cations in the same way that ligand binding is regulated. More information about ab30394 may be found at: http://www.abcam.com/Integrin-beta-1-antibody-12G10-ab30394.html

ab78502 Anti-Integrin beta 1 antibody [P4G11]reacts with calcium-dependent epitopes on the integrin beta 1 subunit. When bound at integrin beta 1, ab78502 activates integrin beta 1 dependent binding to extra cellular matrix substrates. More information about ab78502may be found at: http://www.abcam.com/Integrin-beta-1-antibody-P4G11-ab78502.html

I hope that this information is helpful. Please let me know if you have any questions or there are other ways that Abcam may help you meet your research goals.

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