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Product name
Interferon alpha protein
See all Interferon alpha products (6) ...
Protein description
Highly pure (>98%) recombinant human interferon alpha.
Expression host
CHO
Properties
Purification notes
Sterile filtered Greater than 98% pure by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Concentration
Concentration information loading...
Additional notes
This product exerts its biological activity in a concentration range of 0.005-0.5 ng/ml.
The specific activity as determined in a viral resistance assay was found to be > 1.8 x 108 units/mg.
Sequence notes
Human IFN-alpha is a 19.2 kDa protein containing 165 amino acid residues: CDLPQTHSL GSRRTLMLLA QMRKISLFSC LKDRHDFGFP QEEFGN QFQK AETIPVLHEMIQQIFNLFST KDSSAAWDET LLD KFYTELY QQLNDLEACV IQGVGVTETP LMKEDSILAV RKYFQRITLY LKEKKYSPCA WEVVRAEIMR SFSLSTN LQE SLRSKE
Research areas
Cancer >> Tumor immunology >> Cytokines >> Interferons
Immunology >> Innate Immunity >> Cytokines >> Interferons
Applications
Show applications key
Our Abpromise guarantee covers the use of ab9661 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FuncS: Use at an assay dependent dilution.
SDS-PAGE: Use at an assay dependent dilution.
Protein info
Function
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Sequence similarities
Belongs to the alpha/beta interferon family.
Cellular localization
Secreted.
Target information above from: UniProt accessionP01562
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for Interferon alpha protein (ab9661)
This product has been referenced in:
- Zhang L et al. A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Clin Immunol 125:131-7 (2007). Human.Read more (PubMed: 17825626) »
See 1 publication for this product
Publishing research using ab9661? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"