Anti-Interferon gamma antibody [XMG1.2] (FITC) (ab87030)
- Product nameAnti-Interferon gamma antibody [XMG1.2] (FITC)See all Interferon gamma primary antibodies ...
- DescriptionRat monoclonal [XMG1.2] to Interferon gamma (FITC)
- Tested applicationsICC/IF, Flow Cyt, ELISA more details
- Species reactivityReacts with: Mouse
Recombinant full length Mouse protein expressed in E. coli
- Storage instructionsStore at +4°C in the dark.
- Storage bufferPreservative: Sodium Azide
Constituents: PBS and a stabilizing agent.
- Concentration information loading...
- PurityIgG fraction
- Clonality Monoclonal
- Clone numberXMG1.2
- Light chain typekappa
- Research Areas
Our Abpromise guarantee covers the use of ab87030 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||ICC/IF: Use at an assay dependent dilution.|
|Flow Cyt||Flow Cyt: Use at an assay dependent dilution.|
|ELISA||ELISA: Use at an assay dependent dilution. Ab87303 can be used as a capture antibody in a sandwich ELISA for quantifying mouse IFN-? protein levels. Biotinylated form of the antibody can be paired with a suitable purified capture antibody, with purified recombinant human IFN-? as the standard.|
- FunctionProduced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
- Tissue specificityReleased primarily from activated T lymphocytes.
- Involvement in diseaseIn Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
- Sequence similaritiesBelongs to the type II (or gamma) interferon family.
modificationsProteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
- Cellular localizationSecreted.
- IFG antibodyIFI antibodyIFN gamma antibody
- IFN-gamma antibodyIFNG antibodyIFNG antibodyIFNG_HUMAN antibodyImmune interferon antibodyInterferon gamma antibody
References for Anti-Interferon gamma antibody [XMG1.2] (FITC) (ab87030)
This product has been referenced in:
- Vikingsson A et al. Altered kinetics of CD4+ T cell proliferation and interferon-gamma production in the absence of CD8+ T lymphocytes in virus-infected beta2-microglobulin-deficient mice. Cell Immunol 173:261-8 (1996). Read more (PubMed: 8912885) »
- Hsieh B et al. In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells. J Immunol 156:232-7 (1996). Read more (PubMed: 8598467) »