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Read our guarantee »Overview
Product name
Iodotubercidin
Description
Potent, adenosine kinase inhibitor
Biological description
Potent, specific adenosine kinase inhibitor (IC50 = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).
Purity
> 95%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Molecular Weight
392.15
Chemical structure
Molecular formula
C11H13IN4O4
CAS Number
24386-93-4
Solubility
Soluble in DMSO to 50 mM
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> Adenosine kinase >> Inhibitors
Biochemicals >> Pharmacology >> Receptors & Transporters >> Adenosine >> Other
Biochemicals >> Chemical Type >> Nucleoside
Biochemicals >> Chemical Type >> Biochemicals
References for Iodotubercidin (ab120452)
This product has been referenced in:
- Pignataro G et al. Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. J Cereb Blood Flow Metab 27:1-5 (2007).Read more (PubMed: 16685255) »
- García-Villafranca J & Castro J Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. Biochem Pharmacol 63:1997-2000 (2002).Read more (PubMed: 12093476) »
See all 3 publications for this product
Publishing research using ab120452? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"