Overview

  • Product name
    Irsogladine maleate
  • Description
    Selective PDE4 inhibitor
  • Biological description
    Selective PDE4 inhibitor. Binds mAChR M1. Increases cAMP in surface mucous cells. Facilitates gap-junctional intercellular communication. Shows gastroprotective and antiulcerative effects in vivo.
  • Purity
    > 98%

Properties

  • Chemical name
    6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate
  • Molecular weight
    372.17
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C9H7Cl2N5.C4H4O4
  • CAS Number
    84504-69-8
  • PubChem identifier
    5282435
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC(=C(C=C1Cl)C2=NC(=NC(=N2)N)N)Cl.C(=CC(=O)O)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Yamaguchi H  et al. Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium. Med Mol Morphol 45:140-51 (2012). Read more (PubMed: 23001296) »
  • Kyoi T  et al. Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats. J Pharmacol Sci 95:321-8 (2004). Read more (PubMed: 15272207) »
  • Ueda F  et al. Irsogladine activates gap-junctional intercellular communication through M1 muscarinic acetylcholine receptor. J Pharmacol Exp Ther 274:815-9 (1995). Read more (PubMed: 7543573) »
  • Ueda F  et al. [Synergistic effect of irsogladine maleate and histamine H2-receptor antagonists on experimental gastric ulcers in rats]. Nihon Yakurigaku Zasshi 94:181-8 (1989). Read more (PubMed: 2572521) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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