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AbcamBiochemicals (Asc-142)

Isradipine (ab120142)

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Overview

  • Product nameIsradipine
  • Description
    L-type Ca2+ channel blocker
  • Biological descriptionL-type Ca2+ channel blocker.
  • Purity> 98%

    • Properties

  • Chemical name4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester
  • Molecular Weight371.39
  • Chemical structureChemical Structure
  • Molecular formulaC19H21N3O5
  • CAS Number75695-93-1
  • PubChem identifier3784
  • Storage instructionsStore at +4°C (desiccating conditions).
  • Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 50 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESO=C(OC)C3=C(C)NC(C)=C(C(=O)OC(C)C)C3c1cccc2nonc12
  • Source

    Synthetic

  • Research Areas

    • References for Isradipine (ab120142)

    This product has been referenced in:
    • Berjukow S  et al. Molecular mechanism of calcium channel block by isradipine. Role of a drug-induced inactivated channel conformation. J Biol Chem 275:22114-20 (2000). Read more (PubMed: 10766758) »
    • Zühlke RD  et al. Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene. FEBS Lett 427:220-4 (1998). Read more (PubMed: 9607315) »
    • Rüegg UT & Hof RP Pharmacology of the calcium antagonist isradipine. Drugs 40 Suppl 2:3-9 (1990). Read more (PubMed: 2150637) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"