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Products:Immunology >> Cell Type Markers >> CD >> Myeloid Cells
Overview
Product name
Anti-JAML antibody
See all JAML products (2) ...
Description
Mouse polyclonal to JAML
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
JAML (AAI00798.1, 1 a.a. ~ 355 a.a) full-length human protein.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Tight Junctions
Immunology >> Cell Type Markers >> CD >> Adhesion
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Cell Adhesion Molecules >> Endothelial
Immunology >> Cell Type Markers >> CD >> Myeloid Cells
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Western blot - JAML antibody (ab67843)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab67843 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000.Detects a band of approximately 44 kDa (predicted molecular weight: 44 kDa).
Target
Function
May function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells.
Tissue specificity
Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus.
Sequence similarities
Belongs to the immunoglobulin superfamily.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Domain
The Ig-like V-type domain 2 mediates interaction with CXADR.
Cellular localization
Cell junction. Cell membrane. Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN.
Target information above from: UniProt accessionQ86YT9
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- adhesion molecule AMICA antibody
- Adhesion molecule interacting with CXADR antigen 1 antibody
- adhesion molecule interacts with CXADR antigen 1 antibody
see all
Database links
- Entrez Gene: 120425 Human
- Omim: *609770 Human
- SwissProt: Q86YT9 Human
- Unigene: 16291 Human
Anti-JAML antibody images:
Western blot - JAML antibody (ab67843)
All lanes : Anti-JAML antibody (ab67843) at 1/500 dilution
Lane 1 : JAML transfected 293T cell lysate
Lane 2 : Non transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugate secondary
antibody at 1/2500 dilution
developed using the ECL technique
Predicted band size : 44 kDa
Observed band size : 44 kDa
References for Anti-JAML antibody (ab67843)
ab67843 has not yet been referenced specifically in any publications.
Publishing research using ab67843? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"