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Overview

  • Product nameJHDM1D peptideSee all JHDM1D proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 750 - 850 of Human JHDM1D.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab36972 - JHDM1D antibody.
  • Protein length941 amino acids

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Protein info

    • Alternative names
        JHDM1Djmjc containing proteinJmjC domain-containing histone demethylation protein 1D
        jumonji containing proteinKDM7_HUMANkiaa1718Lysine-specific demethylase 7
      see all
  • FunctionHistone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
  • Sequence similaritiesBelongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
    Contains 1 JmjC domain.
    Contains 1 PHD-type zinc finger.
  • DomainThe PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2.
    The linker region is a critical determinant of demethylase specificity. It prevents the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3, while it favors selectivity toward H3K27me2.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession Q6ZMT4 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for JHDM1D peptide (ab37903)

    ab37903 has not yet been referenced specifically in any publications.

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