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Overview
Product name
Anti-JMJD1C antibody
See all JMJD1C products (4) ...
Description
Mouse monoclonal to JMJD1C
Tested applications
IHC-P, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment: IVMNDQVLEP QNVDPSMVQM TFLDDVVHSL LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT HQQQQQRSIR PNKRKGSD, corresponding to amino acids 2-100 of Human JMJD1C
IVMNDQVLEP QNVDPSMVQM TFLDDVVHSL LKGENIGITS RRRSRANQNV NAVHSHYTRA QANSPRPAMN SQAAVPKQNT HQQQQQRSIR PNKRKGSD
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56538 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
IHC-P
Application notes
WB: Use at a concentration of 1-5 µg/ml.
IHC-P: Use at a concentration of 3 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
Sequence similarities
Belongs to the JHDM2 histone demethylase family.
Contains 1 JmjC domain.
Domain
Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
Post-translational
modifications
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localization
Nucleus.
Target information above from: UniProt accessionQ15652
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- JHD2C_HUMAN antibody
- Jmjd1c antibody
- Jumonji domain containing 1C antibody
see all
Database links
- Entrez Gene: 221037 Human
- Omim: 604503 Human
- SwissProt: Q15652 Human
- Unigene: 413416 Human
- Unigene: 499821 Human
Anti-JMJD1C antibody images:
IHC-P - JMJD1C antibody (ab56538)
JMJD1C antibody (ab56538) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human placenta.
Western blot - JMJD1C antibody (ab56538)
Western blot against tagged recombinant protein immunogen using ab56538 JMJD1C antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa
References for Anti-JMJD1C antibody (ab56538)
ab56538 has not yet been referenced specifically in any publications.
Publishing research using ab56538? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"