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Products:Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Developmental Families >> HOX
Overview
Product name
JMJD3 peptide
See all KDM6B / JMJD3 products (2) ...
Protein description
Synthetic peptide derived from within residues 250 - 350 of Human JMJD3.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab36687 - JMJD3 antibody.
Protein length
1679 amino acids
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Information available upon request.
Concentration
Concentration information loading...
Protein info
Function
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
Sequence similarities
Belongs to the UTX family.
Contains 1 JmjC domain.
Cellular localization
Nucleus.
Target information above from: UniProt accessionO15054
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for JMJD3 peptide (ab38111)
ab38111 has not yet been referenced specifically in any publications.
Publishing research using ab38111? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"