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Anti-JMJD5 antibody (ab28883)

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Overview

Product name

Anti-JMJD5 antibody
See all JMJD5 products (5) ...

Description

Rabbit polyclonal to JMJD5

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse, Rat, Cow, Dog, Caenorhabditis elegans

Immunogen

Synthetic peptide derived from residues 350 - 399 of human JMJD5.

Positive control

Fetal liver lysate

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 2% Sucrose, PBS

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Jumonji containing proteins
Cell Biology >> Other Antibodies >> Other Antibodies
Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Methylation

  • Western blot - JMJD5 antibody (ab28883)Western blot - JMJD5 antibody (ab28883) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab28883 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide1 Image

    WB

     WB: Use a concentration ...Read more →

    WB: Use a concentration of 0.5 µg/mlDetects a band of approximately 50 kDa (predicted molecular weight: 47 kDa).

Target

Function

Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.

Tissue specificity

Weakly expressed in most cells. Highly expressed in breast cancer cells.

Sequence similarities

Contains 1 JmjC domain.

Cellular localization

Nucleus.

Target information above from: UniProt accessionQ8N371 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • FLJ13798 antibody
  • JmjC domain-containing protein 5 antibody
  • JMJD5 antibody
  • JMJD5 protein antibody
  • jumonji domain containing 5 antibody
  • Jumonji domain-containing protein 5 antibody
  • KDM8_HUMAN antibody
  • Lysine-specific demethylase 8 antibody
see all

Database links

see all

Anti-JMJD5 antibody images:

  Western blot - JMJD5 antibody (ab28883)

Western blot - JMJD5 antibody (ab28883)

Anti-JMJD5 antibody (ab28883) at 0.5 µg/ml + Human Fetal Liver Lysate

Secondary
HRP conjugated anti-Rabbit IgG (suggested dilution 1:50,000 - 100,000)
developed using the ECL technique

Predicted band size : 47 kDa
Observed band size : 50 kDa (why is the actual band size different from the predicted?)

References for Anti-JMJD5 antibody (ab28883)

ab28883 has not yet been referenced specifically in any publications.

Publishing research using ab28883? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"