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Anti-JMJD5 antibody (ab36104)

This fast track antibody is not yet fully characterised. It is subject to these terms and conditions

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Overview

Product name

Anti-JMJD5 antibody
See all JMJD5 products (5) ...

Description

Rabbit polyclonal to JMJD5

This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

Cross reactivity

Predicted to work with

Mouse, Rat, Cow, Human

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 350 to the C-terminus of Human JMJD5.

Read Abcam's proprietary immunogen policy

(Peptide available as ab36103.)

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Jumonji containing proteins
Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Methylation

Applications

Application notes

This antibody gave a positive result in ELISA against the immunizing peptide (ab36103).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.

Tissue specificity

Weakly expressed in most cells. Highly expressed in breast cancer cells.

Sequence similarities

Contains 1 JmjC domain.

Cellular localization

Nucleus.

Target information above from: UniProt accessionQ8N371 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • FLJ13798 antibody
  • JmjC domain-containing protein 5 antibody
  • JMJD5 antibody
  • JMJD5 protein antibody
  • jumonji domain containing 5 antibody
  • Jumonji domain-containing protein 5 antibody
  • KDM8_HUMAN antibody
  • Lysine-specific demethylase 8 antibody
see all

Database links

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References for Anti-JMJD5 antibody (ab36104)

ab36104 has not yet been referenced specifically in any publications.

Publishing research using ab36104? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"