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Products:Cell Biology >> Other Antibodies >> Other Antibodies
Overview
Product name
Anti-JPH1 antibody
See all JPH1 products (2) ...
Description
Mouse monoclonal to JPH1
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment: VADEQVTAIV NKPLMSKAPT KEAGAVVPQS KYSGRHHIPN PSNGELHSQY HGYYVKLNAP QHPPVDVEDG DGSSQSSSA, corresponding to amino acids 501-580 of Human JPH1
VADEQVTAIV NKPLMSKAPT KEAGAVVPQS KYSGRHHIPN PSNGELHSQY HGYYVKLNAP QHPPVDVEDG DGSSQSSSA
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Research areas
-
Western blot - JPH1 antibody (ab57425)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab57425 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
JPH1 (Junctophilin 1) contributes to the stabilization of junctional membrane complexes, which are a common feature of all excitable cells and mediate cross talk between the cell surface and intracellular ion channels. It may act by anchoring the plasma membrane and endoplasmic/sarcoplasmic reticulum (ER/SR). It is composed of a C terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane.
Cellular localization
Cell membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum membrane; Single pass type IV membrane protein (By similarity). Sarcoplasmic reticulum membrane; Single pass type IV membrane protein. Note: Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands.
Alternative names
- DKFZp762L0313 antibody
- JP 1 antibody
- JP1 antibody
see all
Database links
- Entrez Gene: 56704 Human
- Omim: 605266 Human
- SwissProt: Q9HDC5 Human
- Unigene: 657367 Human
Anti-JPH1 antibody images:
Western blot - JPH1 antibody (ab57425)
Western blot against tagged recombinant protein immunogen using ab57425 JPH1 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa
References for Anti-JPH1 antibody (ab57425)
ab57425 has not yet been referenced specifically in any publications.
Publishing research using ab57425? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"