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Overview
Product name
Anti-JRK antibody
Description
Mouse polyclonal to JRK
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Full length human JRK protein (AAH43351.1)
Positive control
JRK transfected 293T lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA binding
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Western blot - JRK antibody (ab72683)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab72683 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000.Predicted molecular weight: 57 kDa.
Target
Relevance
The JRK gene is the human homolog of the mouse jerky gene. The encoded protein has similarity to several nuclear regulatory proteins, including centromere protein B, which indicates that it might function as a DNA binding protein. Insertional inactivation of this gene in transgenic mice results in epileptic seizures. JRK is a strong candidate for Childhood Absence Epilepsy (CAE) as it has been mapped to the same chromosomal location (8q24.3). Two transcript variants encoding different isoforms have been found for this gene.
Cellular localization
Nuclear
Alternative names
- Jerky antibody
- Jerky (mouse) homolog antibody
- Jerky homolog (mouse) antibody
- JH8 antibody
Database links
- Entrez Gene: 8629 Human
- Omim: 603210 Human
- SwissProt: O75564 Human
Anti-JRK antibody images:
Western blot - JRK antibody (ab72683)
All lanes : Anti-JRK antibody (ab72683) at 1/500 dilution
Lane 1 : JRK transfected 293T lysate
Lane 2 : Non transfected 293T lysate
Lysates/proteins at 25 µg per lane.
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size : 57 kDa
Observed band size : 62 kDa (why is the actual band size different from the predicted?)
References for Anti-JRK antibody (ab72683)
ab72683 has not yet been referenced specifically in any publications.
Publishing research using ab72683? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"