Anti-Jagged1 antibody [MM0424-4A24] (ab89663)

Overview

• Product nameAnti-Jagged1 antibody [MM0424-4A24]See all Jagged1 primary antibodies ...
• Description
  Mouse monoclonal [MM0424-4A24] to Jagged1
• Tested applicationsWB, Flow Cyt more details
• Species reactivity
  Reacts with: Rat, Human
  
• Immunogen

  Recombinant full length Human Jagged1 protein.

• EpitopeThe epitope is extracellular.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: PBS
• Concentration information loading...
• PurityProtein G purified
• Purification notesThe IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
• Clonality Monoclonal
• Clone numberMM0424-4A24
• IsotypeIgG2
• Research Areas
  • Stem Cells
  • Hematopoietic Progenitors
  • Surface Molecules

  • Stem Cells
  • Signaling Pathways
  • Notch
  • Surface Molecules

  • Cardiovascular
  • Angiogenesis
  • Inhibitors

  • Neuroscience
  • Neurology process
  • Notch Pathway

  • Neuroscience
  • Neurology process
  • Neurogenesis

Applications

Target

• FunctionLigand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
• Tissue specificityWidely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
• Involvement in diseaseDefects in JAG1 are the cause of Alagille syndrome type 1 (ALGS1) [MIM:118450]. Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
  Defects in JAG1 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
• Sequence similaritiesContains 1 DSL domain.
  Contains 15 EGF-like domains.
• Developmental stageExpressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube.
• Cellular localizationMembrane.

Target information above from: UniProt accession P78504 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 182 Human
  • Entrez Gene: 29146 Rat
  • Omim: 601920 Human
  • SwissProt: P78504 Human
  • SwissProt: Q63722 Rat
  • Unigene: 224012 Human
  • Unigene: 88804 Rat

• Alternative names
  AGS antibodyAHD antibodyAWS antibody

  CD 339 antibodyCD339 antibodyCD339 antigen antibodyHeadturner antibodyhJ1 antibodyHtu antibodyJag 1 antibodyJag1 antibodyJAG1_HUMAN antibodyJagged 1 antibodyJagged1 (Alagille syndrome) antibodyJagged1 antibodyJAGL1 antibodyMGC104644 antibodyOTTHUMP00000030278 antibodyProtein jagged-1 antibodySer 1 antibodySer1 antibodySerrate 1 antibodySlalom antibody

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