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Overview

  • Product nameAnti-Jagged1 antibodySee all Jagged1 primary antibodies ...
  • Description
    Rat monoclonal to Jagged1
  • Tested applicationsWB, ICC/IF more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human Jagged1

  • Positive controlCervical adenocarcinoma tissue; HaCat cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab79969 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use at an assay dependent dilution. Detects a band of approximately 134 kDa (predicted molecular weight: 134 kDa).
ICC/IF ICC/IF: Use at an assay dependent dilution.

Target

  • FunctionLigand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
  • Tissue specificityWidely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
  • Involvement in diseaseDefects in JAG1 are the cause of Alagille syndrome type 1 (ALGS1) [MIM:118450]. Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
    Defects in JAG1 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
  • Sequence similaritiesContains 1 DSL domain.
    Contains 15 EGF-like domains.
  • Developmental stageExpressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P78504 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        AGS antibodyAHD antibodyAWS antibody
        CD 339 antibodyCD339 antibodyCD339 antigen antibodyHeadturner antibodyHJ1 antibodyHtu antibodyJag 1 antibodyJag1 antibodyJAG1_HUMAN antibodyJagged 1 antibodyJagged1 (Alagille syndrome) antibodyJagged1 antibodyJAGL1 antibodyMGC104644 antibodyOTTHUMP00000030278 antibodyProtein jagged-1 antibodySer 1 antibodySer-1 antibodySer1 antibodySerrate 1 antibodySerrate-1 antibodySlalom antibody
      see all

    Anti-Jagged1 antibody images

    • Immunocytochemistry/ Immunofluorescence - Jagged1 antibody (ab79969)
      Immunocytochemistry/ Immunofluorescence - Jagged1 antibody (ab79969)
      ab79969 staining in human Jagged1 in HaCat cells co-transfected with Jagged1 (green) and intracellular Notch cDNA (red) by Immunofluorescence.
    • Western blot - Jagged1 antibody (ab79969)
      Western blot - Jagged1 antibody (ab79969)
      All lanes : Anti-Jagged1 antibody (ab79969)

      Lane 1 : Untransfected HaCat cells
      Lane 2 : HaCat cells transfected with an empty vector
      Lane 3 : Transfected HaCat cell line 14
      Lane 4 : Transfected HaCat cell line 23
      Lane 5 : Transfected HaCat cell line 26


      Predicted band size : 134 kDa
      Observed band size : 134 kDa

    References for Anti-Jagged1 antibody (ab79969)

    ab79969 has not yet been referenced specifically in any publications.

    Publishing research using ab79969 ? Please let us know so that we can cite the reference in this datasheet

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