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Anti-JunD antibody (ab425)

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Overview

Product name

Anti-JunD antibody
See all JunD products (8) ...

Description

Rabbit polyclonal to JunD

Specificity

Reacts specifically with 48 kDa protein derived from a transfected CEF cell line.

Tested applications

WB, EMSAmore details

Cross reactivity

Reacts with

Chicken, Human

Predicted to work with

Bird

Immunogen

Fusion protein.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole Serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Cardiovascular >> Heart >> Hypertrophy >> Transcription factors
Epigenetics and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Proto-oncogenes
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> HLH / Leucine Zipper >> Leucine Zipper

Applications

Show applications key

Our Abpromise guarantee covers the use of ab425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

JunD is the most broadly expressed member of the Jun family and the AP1 transcription factor complex. It has been found that primary fibroblasts lacking murine JunD displayed p53-dependent growth arrest, upregulated p19(ARF) expression, and premature senescence. In contrast, immortalized cell lines lacking JunD showed increased proliferation and higher cyclin D1 levels. These properties were reminiscent of the effects of oncogenic RAS expression on primary and established cell cultures. Furthermore, JunD -/- fibroblasts exhibited increased p53-dependent apoptosis upon ultraviolet irradiation and were sensitive to the cytotoxic effects of tumor necrosis factor-alpha. The antiapoptotic role of JunD was confirmed using an in vivo model of TNF-mediated hepatitis. The authors proposed that JunD protects cells from senescence, or apoptotic responses to stress stimuli, by acting as a modulator of the signaling pathways that link RAS to p53.

Cellular localization

Nuclear

Alternative names

  • Activator protein 1 antibody
  • AP 1 antibody
  • AP1 antibody
  • Jun D antibody
  • jun D proto oncogene antibody
  • JunD FL isoform antibody
  • Transcription factor jun D antibody
see all

Database links

References for Anti-JunD antibody (ab425)

This product has been referenced in:

  • Bobrovnikova-Marjon EVet al. Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: role of nuclear factor-kappaB and activating protein-1. Cancer Res 64:4858-69 (2004).Read more (PubMed: 15256456) »

See 1 publication for this product

Publishing research using ab425? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"