Anti-Junctional Adhesion Molecule 2 antibody [CRAM-19 H36] (ab23643)

Please confirm which target these antibodies are detecting, as they have the same clone name [CRAM-19 H36]:  Junctional Adhesion Molecule C antibodies ab16906 ab16889 Junctional Adhesion Molecule 2 antibody ab22539 ab23643 There is some controversy over the naming of this protein family group. Please confirm.

ANSWER:

Thank you once again for your recent enquiries.

I have investigated this case and have obtained the following information for you regarding out JAMC and JAM 2 antibodies. I can understand the confusion, and hope this will help. The SwissProt/Uniprot entry for JAM C states this as JAM 3 and JAM 2, which is where some of the confusion may be. The SwisProt/Uniprot entry link on the datasheet will be the correct one for the target of that antibody.

I can confirm the following:

ab16906 Junctional Adhesion Molecule C antibody [CRAM-18 F26]        This is detecting JAM 3, Junctional adhesion molecule C. The correct Swissprot/Uniprot ID is on the datasheet: http://www.uniprot.org/uniprot/Q9BX67 http://www.uniprot.org/uniprot/B3KWG9

ab22539 Junctional Adhesion Molecule 2 antibody [CRAM-18 F26]    This is the same clone, detecing JAM 3. junctional adhesion molecule C. http://www.uniprot.org/uniprot/Q9D8B7 (I have requested that the SwissProt/Uniprot ID link on our datasheet is corrected as I as there has been an error with this entry on the datasheet, my apologies)

ab23643 Junctional Adhesion Molecule 2 antibody [CRAM-19 H36]     This is a different clone. It detects JAM 2, or JAM C. http://www.uniprot.org/uniprot/P57087

ab16889 Junctional Adhesion Molecule C antibody [19 H36]     Regrettably, I am sorry we had the incorrect clone number for this antibody. I have been informed this this is clone [19 H36]. This is detecting JAM C (JAM 3). http://www.uniprot.org/uniprot/B3KWG9

I hope this will be helpful. If you have any further questions, please do not hesitate to contact us.