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Western blot - KA1 antibody (ab67404)
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - KA1 antibody (ab67404)
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Product Name
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KA1 antibody
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See all KA1 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to KA1
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Immunogen
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A 14 amino acid peptide near the amino terminus of human KA1.
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Reacts with
(species key)
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Hu, Ms, Rat
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Tested applications
(see key)
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IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: Use at an assay dependent dilution.
WB: Use at a concentration of 0.5 - 2 µg/ml. Detects a band of approximately <97 kDa (predicted molecular weight: 107 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Rat brain lysate and human brain tissue.
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Cellular localization
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Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
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Research areas
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Neuroscience >> Neurotransmission >> Receptors / Channels >> Ligand-Gated Ion Channels >> AMPA / Kainate
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Relevance
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KA1 is a high affinity subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of KA1 with both schizophrenia and bipolar disorder.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this KA1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for KA1 antibody images, references, products related to ab67404 and other tools.
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KA1 antibody images:
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 Western blot - KA1 antibody (ab67404)
Lane 1 : KA1 antibody (ab67404) at 0.5 µg/ml
Lane 2 : KA1 antibody (ab67404) at 1 µg/ml
Lane 3 : KA1 antibody (ab67404) at 2 µg/ml
Lane 1 : rat brain lysate
Lane 2 : rat brain lysate
Lane 3 : rat brain lysate
Lysates/proteins at 15 µg per lane.
Predicted band size : 107 kDa
Observed band size : <97 kDa (why is the actual band size different from the predicted?)
Additional bands at : 108 kDa. We are unsure as to the identity of these extra bands.
N.B. Despite its predicted molecular weight, KA1 often migrates at a lower molecular weight in SDS-PAGE.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - KA1 antibody (ab67404)
ab67404 at 2.5µg/ml staining of KA1 in human brain tissue by IHC-P.
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Search PubMed (MEDLINE) for references to KA1
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KA1 antibody - more information
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Customer reviews (feedback) regarding KA1 antibody |
Customer FAQs regarding KA1 antibody |
Protocols for KA1 antibody |
Price and availability of products related to KA1 antibody |
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KA1 antibody - related products:
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KA1 antibody - other tools:
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Contact Abcam with a Technical Enquiry about KA1 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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