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Products:Neuroscience >> Cell Adhesion Proteins >> ECM Proteins
Overview
Product name
Anti-KAL1 antibody
See all KAL1 products (3) ...
Description
Mouse monoclonal to KAL1
Tested applications
Cross reactivity
Reacts with
Recombinant Fragment
Predicted to work with
Human
Immunogen
Recombinant fragment, corresponding to amino acids 548-658 of Human KAL1
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
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Western blot - KAL1 antibody (ab55266)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab55266 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
May be an adhesion-like molecule with anti-protease activity.
Involvement in disease
Defects in KAL1 are the cause of Kallmann syndrome type 1 (KAL1) [MIM:308700]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
Sequence similarities
Contains 4 fibronectin type-III domains.
Contains 1 WAP domain.
Post-translational
modifications
N-glycosylated.
Cellular localization
Cell surface.
Target information above from: UniProt accessionP23352
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- KAL antibody
- Adhesion molecule-like X-linked antibody
- ADMLX antibody
see all
Database links
- Entrez Gene: 3730 Human
- Omim: 300836 Human
- SwissProt: P23352 Human
- Unigene: 521869 Human
Anti-KAL1 antibody images:
Western blot - KAL1 antibody (ab55266)
Western blot against tagged recombinant protein immunogen using ab55266 KAL1 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
References for Anti-KAL1 antibody (ab55266)
ab55266 has not yet been referenced specifically in any publications.
Publishing research using ab55266? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"