KAT13C / NCOA2 antibody - ChIP Grade (ab9261)

Product Name 

KAT13C / NCOA2 antibody - ChIP Grade

Product type 

Primary antibodies

Description 

Rabbit polyclonal to KAT13C / NCOA2 - ChIP Grade

Immunogen 

Synthetic peptide (Human) conjugated to KLH - which represents aportion between residues 600 and 700 of the human Nuclear Receptor Coactivator 2 (GenBank PID 1877215).

Reacts with 
(species key)

Hu

Tested applications 
(see key)

ChIP, IP, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions
ChIP: Use at an assay dependent dilution.
IP: Use at a concentration of 1 - 4 µg/ml.
WB: 1/500 - 1/5000. Predicted molecular weight: 159 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Nuclear

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Chromatin and Nuclear Signaling >> ChIP'ing antibodies >> ChIP'ing antibodies
Chromatin and Nuclear Signaling >> Transcription >> Mediator Complex
Chromatin and Nuclear Signaling >> Transcription >> Other factors
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Co-activators/co-repressors

Relevance 

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcriptional activity of the nuclear receptor with which they associate. One such coactivator is KAT13C / nuclear receptor coactivator 2 (NCOA2), also termed Glucocorticoid receptor-interacting protein 1 (GRIP1).

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.1% Sodium Azide
Constituents: Tris citrate/phosphate, pH 7-8

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

Antibodies were affinity purified usingthe peptide immobilized on solid support. Antibody concentration was determined by extinction coefficient: absorbance at 280 nmof 1.4 equals 1.0 mg of IgG.

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Store at +4°C.

References for KAT13C / NCOA2 antibody - ChIP Grade (ab9261)

  This product has been used in: (two most recent references)

Cvoro A et al. Selective estrogen receptor-beta agonists repress transcription of proinflammatory genes. J Immunol 180:630-6 (2008). ChIP; Human. PubMed: 18097065

Levy N et al. Differential regulation of native estrogen receptor-regulatory elements by estradiol, tamoxifen, and raloxifene. Mol Endocrinol 22:287-303 (2008). ChIP; Human. PubMed: 17962382

See all 4 publication references for this product.


If you publish research using ab9261 please let us know so that we can cite the reference on this datasheet.

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