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Products:Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Acetylation >> HAT
Overview
Product name
Anti-Histone acetyltransferase MYST3 antibody
See all Histone acetyltransferase MYST3 products (3) ...
Description
Rabbit polyclonal to Histone acetyltransferase MYST3
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide surrounding amino acid 1991 of human HAT3.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Thimerosal (merthiolate)
Constituents: 50% Glycerol, 1% BSA, PBS
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Acetylation >> HAT
Applications
Show applications key
Our Abpromise guarantee covers the use of ab41718 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Application notes
WB: Use at a concentration of 2 - 6 µg/ml. Detects a band of approximately 220 kDa (predicted molecular weight: 222 kDa). A 50kDa unknown band can also be detected.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.
Involvement in disease
Note=Chromosomal aberrations involving MYST3 may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ and the C-terminus part of NCOA2/TIF2. MYST3-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
Note=A chromosomal aberration involving MYST3 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a MYST3-ASXL2 fusion protein.
Sequence similarities
Belongs to the MYST (SAS/MOZ) family.
Contains 1 C2HC-type zinc finger.
Contains 1 H15 (linker histone H1/H5 globular) domain.
Contains 2 PHD-type zinc fingers.
Domain
The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
Post-translational
modifications
Autoacetylated.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localization
Nucleus. Partially concentrated in subnuclear foci distinct from PML bodies, and excluded from the nucleoli.
Target information above from: UniProt accessionQ92794
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- SAS2 and TIP60 protein 3 antibody
- HAT 3 antibody
- Histone acetyltransferase MYST3 antibody
see all
Database links
- Entrez Gene: 7994 Human
- Omim: 601408 Human
- SwissProt: Q92794 Human
- Unigene: 491577 Human
- Unigene: 591848 Human
References for Anti-Histone acetyltransferase MYST3 antibody (ab41718)
This product has been referenced in:
- Paggetti Jet al. Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells. Oncogene 29:5019-31 (2010). WB; Human.Read more (PubMed: 20581860) »
See 1 publication for this product
Publishing research using ab41718? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"