Overview

  • Product name
    KC 12291 hydrochloride
  • Description
    Atypical voltage-gated Na+ channel blocker
  • Biological description
    Atypical voltage-gated Na+ channel blocker. Shows moderate inhibitory effects on peak (or rapid) Na+ currents. Markedly reduces sustained, slow and non-inactivating Na+ current. Reduces Na+ influx through voltage-gated Na+ channels. Orally active.
  • Purity
    > 97%

Properties

  • Chemical name
    N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methyl-3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propan-1-amine hydrochloride
  • Molecular weight
    449.99
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C22H27N3O3S.HCl
  • CAS Number
    181936-98-1
  • PubChem identifier
    22902387
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 25 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CN(CCCOC1=NSC(=N1)C2=CC=CC=C2)CCC3=CC(=C(C=C3)OC)OC.Cl
  • Source

    Synthetic

  • Research areas

    References for KC 12291 hydrochloride (ab141817)

    This product has been referenced in:
    • John GW  et al. KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc Drug Rev 22:17-26 (2004). Read more (PubMed: 14978516) »
    • Decking UK  et al. Cardioprotective actions of KC 12291. I. Inhibition of voltage-gated Na+ channels in ischemia delays myocardial Na+ overload. Naunyn Schmiedebergs Arch Pharmacol 358:547-53 (1998). Read more (PubMed: 9840423) »
    • Hartmann M  et al. Cardioprotective actions of KC 12291. II. Delaying Na+ overload in ischemia improves cardiac function and energy status in reperfusion. Naunyn Schmiedebergs Arch Pharmacol 358:554-60 (1998). Read more (PubMed: 9840424) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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