Anti-KCNA3 antibody (ab61200)
Key features and details
- Rabbit polyclonal to KCNA3
- Suitable for: ICC/IF, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-KCNA3 antibody
See all KCNA3 primary antibodies -
Description
Rabbit polyclonal to KCNA3 -
Host species
Rabbit -
Tested applications
Suitable for: ICC/IF, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic non-phosphopeptide derived from human KCNA3 around the phosphorylation site of tyrosine 135.
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Positive control
- Human brain tissue and HuvEc cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab61200 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab61200 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ICC/IF |
1/100 - 1/500.
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IHC-P |
1/50 - 1/100.
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Notes |
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ICC/IF
1/100 - 1/500. |
IHC-P
1/50 - 1/100. |
Target
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Function
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. -
Sequence similarities
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. -
Domain
The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3738 Human
- Entrez Gene: 16491 Mouse
- Omim: 176263 Human
- SwissProt: P22001 Human
- SwissProt: P16390 Mouse
- Unigene: 169948 Human
- Unigene: 30640 Mouse
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Alternative names
- HGK 5 antibody
- HGK5 antibody
- HLK 3 antibody
see all
Images
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ab61200 at 1/50 dilution staining KCNA3 in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence (left) or presence (right) of the immunising peptide.
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ab61200 at 1/100 dilution staining KCNA3 in HuvEc cells by Immunofluorescence, in the absence (left) or presence (right) of the immunising peptide.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab61200 has not yet been referenced specifically in any publications.