Anti-KCNA5 antibody (ab110469)

Overview

• Product nameAnti-KCNA5 antibodySee all KCNA5 primary antibodies ...
• Description
  Rabbit polyclonal to KCNA5
• Specificityab110469 detects endogenous levels of total KCNA5 protein.
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat
• Immunogen

  Synthetic peptide derived from an internal region of Human KCNA5 (UniProt ID: P22460).

• Positive controlExtracts from 293 cells.

Properties

• FormLiquid
• Storage instructionsStore at -20°C. Stable for 12 months at -20°C
• Storage bufferpH: 7.40
  Preservative: 0.02% Sodium azide
  Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab110469 was affinity purified from Rabbit antiserum by affinity chromatography using epitope specific immunogen.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Hypoxia

  • Metabolism
  • Types of disease
  • Cancer

  • Cancer
  • Cancer Metabolism
  • Response to hypoxia

  • Cardiovascular
  • Vasculature
  • Vasoconstriction
  • Other

  • Cardiovascular
  • Hypoxia
  • Hypoxia-Regulated

  • Cardiovascular
  • Heart
  • Cardiac arrhythmias

  • Neuroscience
  • Neurotransmission
  • Receptors / Channels
  • Potassium Channels

Applications

Target

• FunctionMediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.
• Tissue specificityPancreatic islets and insulinoma.
• Involvement in diseaseDefects in KCNA5 are the cause of atrial fibrillation familial type 7 (ATFB7) [MIM:612240]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.
• Sequence similaritiesBelongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
• DomainThe amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
• Post-translational
  modificationsSumoylated on Lys-221, and Lys-536, preferentially by SUMO3. Sumoylation regulates the voltage sensitivity of the channel.
• Cellular localizationMembrane.

Target information above from: UniProt accession P22460 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 3741 Human
  • Entrez Gene: 16493 Mouse
  • Entrez Gene: 25470 Rat
  • Omim: 176267 Human
  • SwissProt: P22460 Human
  • SwissProt: Q61762 Mouse
  • SwissProt: P19024 Rat
  • Unigene: 150208 Human

  • Unigene: 222831 Mouse
  • Unigene: 162789 Rat

  see all

• Alternative names
  HPCN1 antibodyKCNA5 antibodyKCNA5_HUMAN antibody

  KV1.5 antibodyPotassium voltage gated channel subfamily A member 5 antibodyPotassium voltage-gated channel subfamily A member 5 antibodyVoltage gated potassium channel subunit Kv1.5 antibodyVoltage-gated potassium channel HK2 antibodyVoltage-gated potassium channel subunit Kv1.5 antibody

  see all

Anti-KCNA5 antibody images

• 

  Western blot - KCNA5 antibody (ab110469)
  All lanes : Anti-KCNA5 antibody (ab110469) at 1/500 dilution
  
  Lane 1 : Extracts from 293 cells
  Lane 2 : Extracts from 293 cells, treated with synthesized peptide
  
  Lysates/proteins at 30 µg per lane.
  
  
  Predicted band size : 67 kDa