Overview

  • Product nameAnti-KCNA5 antibody
    See all KCNA5 primary antibodies
  • Description
    Rabbit polyclonal to KCNA5
  • Specificityab110469 detects endogenous levels of total KCNA5 protein.
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from an internal region of Human KCNA5 (UniProt ID: P22460).

  • Positive control
    • Extracts from 293 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab110469 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 67 kDa.

Target

  • FunctionMediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.
  • Tissue specificityPancreatic islets and insulinoma.
  • Involvement in diseaseDefects in KCNA5 are the cause of atrial fibrillation familial type 7 (ATFB7) [MIM:612240]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.
  • Sequence similaritiesBelongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
  • DomainThe amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Post-translational
    modifications
    Sumoylated on Lys-221, and Lys-536, preferentially by SUMO3. Sumoylation regulates the voltage sensitivity of the channel.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ATFB7 antibody
    • cardiac potassium channel antibody
    • HCK1 antibody
    • HK2 antibody
    • HPCN1 antibody
    • insulinoma and islet potassium channel antibody
    • KCNA5 antibody
    • KCNA5_HUMAN antibody
    • KV1.5 antibody
    • PCN1 antibody
    • potassium channel 1 antibody
    • Potassium channel, insulinoma and islet cell antibody
    • Potassium channel, voltage-gated, shaker-related subfamily, member 5 antibody
    • Potassium voltage gated channel subfamily A member 5 antibody
    • Potassium voltage-gated channel subfamily A member 5 antibody
    • Voltage gated potassium channel subunit Kv1.5 antibody
    • Voltage-gated potassium channel HK2 antibody
    • voltage-gated potassium channel protein Kv1.5 antibody
    • Voltage-gated potassium channel subunit Kv1.5 antibody
    see all

Anti-KCNA5 antibody images

  • All lanes : Anti-KCNA5 antibody (ab110469) at 1/500 dilution

    Lane 1 : Extracts from 293 cells
    Lane 2 : Extracts from 293 cells, treated with synthesized peptide

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 67 kDa

References for Anti-KCNA5 antibody (ab110469)

ab110469 has not yet been referenced specifically in any publications.

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