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Anti-KCNE1 antibody - Cytoplasmic domain (ab86199)

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Overview

Product name

Anti-KCNE1 antibody - Cytoplasmic domain
See all KCNE1 products (4) ...

Description

Rabbit polyclonal to KCNE1 - Cytoplasmic domain

Tested applications

WB, IHC-P, IHC-Frmore details

Cross reactivity

Reacts with

Human

Immunogen

Synthetic peptide derived from the cytoplasmic domain of Human KCNE1, conjugated to an immunogenic carrier protein

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Cardiovascular >> Heart >> Cardiac arrhythmias
Neuroscience >> Sensory System >> Auditory system
Neuroscience >> Neurotransmission >> Receptors / Channels >> Potassium Channels

Applications

Show applications key

Our Abpromise guarantee covers the use of ab86199 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

  • IHC-P

     

  • IHC-Fr

     

Application notes

IHC-P: 1/300 - 1/2000. Antigen retrieval recommended.
IHC-Fr: 1/300 - 1/2000.
WB: 1/300 - 1/2000. Predicted molecular weight: 15 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

KCNE1 (Potassium voltage-gated channel subfamily E member 1) is an ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. It modulates the gating kinetics and enhances stability of the channel complex. KCNE1 assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. KCNE1 assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Defects in KCNE1 are a cause of the autosomal recessive Jervell and Lange-Nielsen syndrome (JLNS). JLNS comprises profound congenital sensorineural deafness associated with syncopal episodes. These are caused by ventricular tachyarrhythmia secondary to abnormal repolarization, manifested by a prolonged QT interval on the electrocardiogram.

Cellular localization

Membrane; Single-pass type I membrane protein.

Alternative names

  • Delayed rectifier potassium channel subunit IsK antibody
  • Human cardiac delayed rectifier potassium channel protein antibody
  • IKs producing slow voltage gated potassium channel subunit beta Mink antibody
  • ISK antibody
  • JLNS 2 antibody
  • JLNS antibody
  • JLNS2 antibody
  • KCNE 1 antibody
  • LQT 5 antibody
  • LQT5 antibody
  • MGC33114 antibody
  • Minimal potassium channel antibody
  • MinK antibody
  • Potassium voltage gated channel Isk related family member 1 antibody
  • Potassium voltage gated channel Isk related subfamily member 1 antibody
  • Potassium voltage gated channel subfamily E member 1 antibody
see all

Database links

References for Anti-KCNE1 antibody - Cytoplasmic domain (ab86199)

ab86199 has not yet been referenced specifically in any publications.

Publishing research using ab86199? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"