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Read our guarantee »Products:Neuroscience >> Neurotransmission >> Receptors / Channels >> Potassium Channels
Anti-KCNE1 antibody - Cytoplasmic domain
See all KCNE1 products (4) ...
Rabbit polyclonal to KCNE1 - Cytoplasmic domain
WB, IHC-P, IHC-Frmore details
Reacts with
Human
Synthetic peptide derived from the cytoplasmic domain of Human KCNE1, conjugated to an immunogenic carrier protein
Liquid
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
Preservative: None
Constituents: Whole serum
Whole antiserum
Polyclonal
IgG
Cardiovascular >> Heart >> Cardiac arrhythmias
Neuroscience >> Sensory System >> Auditory system
Neuroscience >> Neurotransmission >> Receptors / Channels >> Potassium Channels
Our Abpromise guarantee covers the use of ab86199 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/300 - 1/2000. Antigen retrieval recommended.
IHC-Fr: 1/300 - 1/2000.
WB: 1/300 - 1/2000. Predicted molecular weight: 15 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
KCNE1 (Potassium voltage-gated channel subfamily E member 1) is an ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. It modulates the gating kinetics and enhances stability of the channel complex. KCNE1 assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. KCNE1 assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Defects in KCNE1 are a cause of the autosomal recessive Jervell and Lange-Nielsen syndrome (JLNS). JLNS comprises profound congenital sensorineural deafness associated with syncopal episodes. These are caused by ventricular tachyarrhythmia secondary to abnormal repolarization, manifested by a prolonged QT interval on the electrocardiogram.
Membrane; Single-pass type I membrane protein.
ab86199 has not yet been referenced specifically in any publications.
Publishing research using ab86199? Please let us know so that we can cite the reference in this datasheet
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