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Product Name
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KCNE1 antibody - Cytoplasmic domain
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See all KCNE1 antibodies (4)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to KCNE1 - Cytoplasmic domain
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Immunogen
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Synthetic peptide derived from the cytoplasmic domain of Human KCNE1, conjugated to an immunogenic carrier protein
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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IHC-Fr, IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions IHC-P: 1/300 - 1/2000. Antigen retrieval recommended. IHC-Fr: 1/300 - 1/2000. WB: 1/300 - 1/2000. Predicted molecular weight: 15 kDa.
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; Single-pass type I membrane protein.
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Research areas
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Cardiovascular >> Heart >> Cardiac arrhythmias Neuroscience >> Sensory System >> Auditory system Neuroscience >> Neurotransmission >> Receptors / Channels >> Potassium Channels
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Relevance
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KCNE1 (Potassium voltage-gated channel subfamily E member 1) is an ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. It modulates the gating kinetics and enhances stability of the channel complex. KCNE1 assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. KCNE1 assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Defects in KCNE1 are a cause of the autosomal recessive Jervell and Lange-Nielsen syndrome (JLNS). JLNS comprises profound congenital sensorineural deafness associated with syncopal episodes. These are caused by ventricular tachyarrhythmia secondary to abnormal repolarization, manifested by a prolonged QT interval on the electrocardiogram.
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Database links
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The links below go to external sites and will open in a new browser window
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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Preservative: None Constituents: Whole serum
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this KCNE1 antibody - Cytoplasmic domain is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to KCNE1
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