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Western blot - KCNE1 antibody (ab55274)
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Product Name
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KCNE1 antibody
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See all KCNE1 antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal to KCNE1
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Immunogen
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Recombinant fragment: RSKKLEHSND PFNVYIESDA WQEKDKAYVQ ARVLESYRSC YVVENHLAIE QPNTHLPETK PSP, corresponding to amino acids 67-130 of Human KCNE1
BLAST 'RSKKLEHSND PFNVYIESDA WQEKDKAYVQ ARVLESYRSC YVVENHLAIE QPNTHLPETK ' with  or 
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Reacts with
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RecFrag
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Predicted to react
(species key)
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Hu
(Due to sequence homology)
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; Single-pass type I membrane protein.
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Research areas
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Cardiovascular >> Heart >> Cardiac arrhythmias
Neuroscience >> Sensory System >> Auditory system
Neuroscience >> Neurotransmission >> Receptors / Channels >> Potassium Channels
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Relevance
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KCNE1 (Potassium voltage-gated channel subfamily E member 1) is an ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. It modulates the gating kinetics and enhances stability of the channel complex. KCNE1 assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. KCNE1 assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Defects in KCNE1 are a cause of the autosomal recessive Jervell and Lange-Nielsen syndrome (JLNS). JLNS comprises profound congenital sensorineural deafness associated with syncopal episodes. These are caused by ventricular tachyarrhythmia secondary to abnormal repolarization, manifested by a prolonged QT interval on the electrocardiogram.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Isotype
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IgG1
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
PBS, pH 7.2
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this KCNE1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for KCNE1 antibody images, references, products related to ab55274 and other tools.
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KCNE1 antibody images:
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 Western blot - KCNE1 antibody (ab55274)
Western blot against tagged recombinant protein immunogen using ab55274 KCNE1 antibody at 1ug/ml. Predicted band size of immunogen is 33 kDa. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
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Search PubMed (MEDLINE) for references to KCNE1
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KCNE1 antibody - more information
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Customer reviews (feedback) regarding KCNE1 antibody |
Customer FAQs regarding KCNE1 antibody |
Protocols for KCNE1 antibody |
Price and availability of products related to KCNE1 antibody |
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KCNE1 antibody - related products:
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KCNE1 antibody - other tools:
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Contact Abcam with a Technical Enquiry about KCNE1 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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