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Products:Neuroscience >> Neurotransmission >> Receptors / Channels >> Potassium Channels
Overview
Product name
Anti-KCNE1 antibody
See all KCNE1 products (4) ...
Description
Rabbit polyclonal to KCNE1
Tested applications
WB, Indirect ELISAmore details
Cross reactivity
Reacts with
Recombinant Fragment
Predicted to work with
Human
Immunogen
Synthetic peptide corresponding to N-terminal residues of KCNE1 (Potassium voltage-gated channel subfamily E member 1) (Human)
Properties
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Heart >> Cardiac arrhythmias
Neuroscience >> Sensory System >> Auditory system
Neuroscience >> Neurotransmission >> Receptors / Channels >> Potassium Channels
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56008 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/mlPredicted molecular weight: 15 kDa.(for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.)
I-ELISA: Use at an assay dependent dilution.
Target
Relevance
KCNE1 (Potassium voltage-gated channel subfamily E member 1) is an ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. It modulates the gating kinetics and enhances stability of the channel complex. KCNE1 assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. KCNE1 assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Defects in KCNE1 are a cause of the autosomal recessive Jervell and Lange-Nielsen syndrome (JLNS). JLNS comprises profound congenital sensorineural deafness associated with syncopal episodes. These are caused by ventricular tachyarrhythmia secondary to abnormal repolarization, manifested by a prolonged QT interval on the electrocardiogram.
Cellular localization
Membrane; Single-pass type I membrane protein.
Alternative names
- Delayed rectifier potassium channel subunit IsK antibody
- Human cardiac delayed rectifier potassium channel protein antibody
- IKs producing slow voltage gated potassium channel subunit beta Mink antibody
see all
Database links
- Entrez Gene: 3753 Human
- Omim: 176261 Human
- SwissProt: P15382 Human
- Unigene: 121495 Human
References for Anti-KCNE1 antibody (ab56008)
ab56008 has not yet been referenced specifically in any publications.
Publishing research using ab56008? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"