KCNE1 antibody (ab56008)

Product Name 

KCNE1 antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to KCNE1

Immunogen 

Synthetic peptide corresponding to N-terminal residues of KCNE1 (Potassium voltage-gated channel subfamily E member 1) (Human)

Reacts with 
(species key)

Hu

Tested applications 
(see key)

I-ELISA, WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
I-ELISA: Use at an assay dependent dilution.
WB: Use at a concentration of 1 µg/ml for 2 hrs. Predicted molecular weight: 15 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Membrane; Single-pass type I membrane protein.

Research areas 

Cardiovascular >> Heart >> Cardiac arrhythmias
Neuroscience >> Sensory System >> Auditory system
Neuroscience >> Neurotransmission >> Receptors / Channels >> Potassium Channels

Relevance 

KCNE1 (Potassium voltage-gated channel subfamily E member 1) is an ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. It modulates the gating kinetics and enhances stability of the channel complex. KCNE1 assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. KCNE1 assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Defects in KCNE1 are a cause of the autosomal recessive Jervell and Lange-Nielsen syndrome (JLNS). JLNS comprises profound congenital sensorineural deafness associated with syncopal episodes. These are caused by ventricular tachyarrhythmia secondary to abnormal repolarization, manifested by a prolonged QT interval on the electrocardiogram.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.500 mg/ml

Storage instructions 

Store at -20°C. Stable for 12 months at -20°C

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