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Overview

  • Product nameKCNH1 protein (Human)
  • Protein descriptionRecombinant fragment of Human KCNH1 (amino acids 890-988) with N terminal proprietary tag; Predicted MW 36.52 kDa (UniProt: O95259).
  • Uniprot accessionO95259
  • Molecular weight36.520kDa inclusive of tags
  • Protein length99 amino acids
  • Expression hostWheat germ

    • Properties

  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl
  • Concentration information loading...
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • SequenceRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEV RHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQE LFEISRPQSPESERDIFGA
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab116850 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA ELISA: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    WB WB: Use at an assay dependent concentration. (Recombinant protein).

    Protein info

    • Alternative names
        EAGEAG channel 1EAG1
        Ether a go go potassium channel 1Ether-a-go-go potassium channel 1h eagh-eaghEAG1Kcnh1KCNH1_HUMANKv10.1M eagMGC124419MGC124420MGC142269Potassium voltage gated channel subfamily H (eag related), member 1Potassium voltage-gated channel subfamily H member 1Voltage gated potassium channel subunit Kv10.1Voltage-gated potassium channel subunit Kv10.1
      see all
  • FunctionPore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts.
  • Tissue specificityHighly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.
  • Sequence similaritiesBelongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily.
    Contains 1 cyclic nucleotide-binding domain.
    Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.
  • DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession O95259 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    KCNH1 protein (Human) images

    • SDS-PAGE - KCNH1 protein (Tagged) (ab116850)
      SDS-PAGE - KCNH1 protein (Tagged) (ab116850)
      12.5% SDS-PAGE stained with Coomassie Blue showing ab116850 at approximately 36.52 kDa.

    References for KCNH1 protein (Human) (ab116850)

    ab116850 has not yet been referenced specifically in any publications.

    Publishing research using ab116850 ? Please let us know so that we can cite the reference in this datasheet

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