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Anti-KCNH8 antibody (ab86213)

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Overview

Product name

Anti-KCNH8 antibody
See all KCNH8 products (3) ...

Description

Rabbit polyclonal to KCNH8

Tested applications

WB, IHC-P, IHC-Frmore details

Cross reactivity

Reacts with

Rat

Predicted to work with

Mouse

Immunogen

A synthetic peptide from the N terminal region of rat KCNH8, conjugated to an immunogenic carrier protein.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum, 1X PBS

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Neuroscience >> Neurotransmission >> Receptors / Channels >> Potassium Channels

Applications

Show applications key

Our Abpromise guarantee covers the use of ab86213 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

  • IHC-P

     

  • IHC-Fr

     

Application notes

IHC-P: 1/300 - 1/2000. Antigen retrieval is recommended.
IHC-Fr: 1/300 - 1/2000.
WB: 1/300 - 1/2000. Predicted molecular weight: 123 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.

Tissue specificity

Primarily expressed in the nervous system.

Sequence similarities

Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.
Contains 1 cyclic nucleotide-binding domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 1 PAS (PER-ARNT-SIM) domain.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Cellular localization

Membrane.

Target information above from: UniProt accessionQ96L42 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • ELK1 antibody
  • elk3 antibody
  • Kv12.1 antibody
  • Voltage-gated potassium channel subunit Kv12.1 antibody
  • C130090D05Rik antibody
  • ELK antibody
  • ELK channel 3 antibody
  • Ether-a-go-go-like potassium channel 1 antibody
  • Ether-a-go-go-like potassium channel 3 antibody
  • hElk1 antibody
  • Kcnh8 antibody
  • KCNH8_HUMAN antibody
  • Potassium voltage gated channel, subfamily H (eag-related), member 8 antibody
  • Potassium voltage-gated channel subfamily H member 8 antibody
  • Potassium voltage-gated channel, subfamily H, member 8 antibody
see all

Database links

References for Anti-KCNH8 antibody (ab86213)

ab86213 has not yet been referenced specifically in any publications.

Publishing research using ab86213? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"