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Product Name
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KCNJ1 antibody - Cytoplasmic domain
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See all KCNJ1 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to KCNJ1 - Cytoplasmic domain
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Immunogen
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A synthetic peptide from the cytoplasmic domain of Human KCNJ1 conjugated to an immunogenic carrier protein.
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Reacts with
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Hu
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Predicted to react
(species key)
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Ms, Rat
(Due to sequence homology)
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Tested applications
(see key)
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IHC-Fr, IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: Use at a concentration of 10 - 50 µg/ml. Antigen retrieval is not essential but may optimise staining.
IHC-Fr: Use at a concentration of 10 - 50 µg/ml.
WB: Use at a concentration of 10 - 50 µg/ml. Predicted molecular weight: 45 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; Multi-pass membrane protein.
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Research areas
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Signal Transduction >> Metabolism >> Plasma Membrane >> Channels
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Other
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Relevance
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Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. KCNJ1 is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The KCNJ1 channel is blocked by external barium. WNK1 has been shown to inhibit KCNJ1 by enhancing its endocytosis. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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IgG fraction
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Storage buffer
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Preservative: None
Constituents: 1X PBS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this KCNJ1 antibody - Cytoplasmic domain is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to KCNJ1
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